Omeprazole, Furazolidone, and Tetracycline: an eradication treatment for resistant H. pylori in Brazilian patients with peptic ulcer disease
Rev. Hosp. Clin. Fac. Med. Univ. Säo Paulo
;
57(5): 205-208, Sept.-Oct. 2002. tab
Article
in English
| LILACS
| ID: lil-325551
ABSTRACT
OBJECTIVES:
To determine the efficacy of a simple, short-term and low-cost eradication treatment for Helicobacter pylori (H. pylori) using omeprazole, tetracycline, and furazolidone in a Brazilian peptic ulcer population, divided into 2 subgroups untreated and previously treated for the infection. PATIENTS ANDMETHODS:
Patients with peptic ulcer disease diagnosed by endoscopic examination and infected by H. pylori diagnosed by the rapid urease test (RUT) and histological examination, untreated and previously unsuccessfully treated by macrolides and nitroimidazole, were medicated with omeprazole 20 mg daily dose and tetracycline 500 mg and furazolidone 200 mg given 3 times a day for 7 days. Another endoscopy or a breath test was performed 12 weeks after the end of treatment. Patients were considered cured of the infection if a RUT and histologic examination proved negative or a breath test was negative for the bacterium.RESULTS:
Sixty-four patients were included in the study. The women were the predominant sex (58 percent); the mean age was 46 years. Thirty-three percent of the patients were tobacco users, and duodenal ulcer was identified in 80 percent of patients. For the 59 patients that underwent follow-up examinations, eradication was verified in 44 (75 percent). The eradication rate for the intention-to-treat group was 69 percent. The incidence of severe adverse effects was 15 percent.CONCLUSION:
The treatment provides good efficacy for H. pylori eradication in patients who were previously treated without success, but it causes severe adverse effects that prevented adequate use of the medications in 15 percent of the patients
Full text:
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Index:
LILACS (Americas)
Main subject:
Peptic Ulcer
/
Tetracycline
/
Omeprazole
/
Helicobacter pylori
/
Helicobacter Infections
/
Furazolidone
/
Anti-Ulcer Agents
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Rev. Hosp. Clin. Fac. Med. Univ. Säo Paulo
Journal subject:
Medicine
Year:
2002
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
University of Säo Paulo/BR
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