HIV-1 polymorphism: a challenge for vaccine development - a review
Mem. Inst. Oswaldo Cruz
;
97(2): 143-150, Mar. 2002. mapas
Article
in English
| LILACS
| ID: lil-326299
RESUMO
The perspective for the development of anti-HIV/AIDS vaccines became a target sought by several research groups and pharmaceutical companies. However, the complex virus biology in addition to a striking genetic variability and the limited understanding of the immunological correlates of protection have made this an enormous scientific challenge not overcome so far. In this review we presented an updating of HIV-1 subtypes and recombinant viruses circulating in South American countries, focusing mainly on Brazil, as one of the challenges for HIV vaccine development. Moreover, we discussed the importance of stimulating developing countries to participate in the process of vaccine evaluation, not only testing vaccines according to already defined protocols, but also working together with them, in order to take into consideration their local information on virus diversity and host genetic background relevant for the vaccine development and testing, as well as including local virus based reagents to evaluate the immunogenicity of the candidate vaccines
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Polymorphism, Genetic
/
HIV-1
/
AIDS Vaccines
Limits:
Humans
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2002
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Fundaçäo Instituto Oswaldo Cruz/BR
/
Instituto Oswaldo Cruz-Fiocruz/BR
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