Effects of chloroquine and sulfadoxine/pyrimethamine on gametocytes in patients with uncomplicated Plasmodium falciparum malaria in Colombia
Mem. Inst. Oswaldo Cruz
;
97(8): 1221-1223, Dec. 15, 2002. tab, graf
Article
in English
| LILACS
| ID: lil-326331
ABSTRACT
The effect of antimalarials on gametocytes can influence transmission and the spread of drug resistance. In order to further understand this relationship, we determined the proportion of gametocyte carriers over time post-treatment in patients with uncomplicated Plasmodium falciparum malaria who were treated with either chloroquine (CQ) or sulfadoxine/pyrimethamine (SP). The overall proportion of gametocyte carriers was high (85 percent) and not statistically significantly different between the CQ and SP treatment groups. However, an increased risk of carrying gametocytes on day 14 of follow up (1.26 95 percent CI 1.10-1.45) was found among patients having therapeutic failure to CQ compared with patients having an adequate therapeutic response. This finding confirms and extends reports of increased risk of gametocytaemia among CQ resistant P. falciparum
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Plasmodium falciparum
/
Pyrimethamine
/
Sulfadoxine
/
Chloroquine
/
Malaria, Falciparum
/
Gametogenesis
/
Antimalarials
Type of study:
Controlled clinical trial
Limits:
Animals
/
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Colombia
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2002
Type:
Article
/
Project document
Affiliation country:
Colombia
Institution/Affiliation country:
Centro Internacional de Entrenamiento e Investigaciones Médicas/CO
Similar
MEDLINE
...
LILACS
LIS