La sobredosis de paracetamol y la colestasis experimental inducen la expresión de los genes que codifican la P-glicoprotína tipo 1 en ratas / Paracetamol overdose and experimental cholestasis induced gene expresion that codified P-glicoprotein tipe 1 in rats
Acta gastroenterol. latinoam
;
32(2): 79-82, nov. 2002. ilus, tab
Article
in Spanish
| LILACS
| ID: lil-327727
ABSTRACT
Excretion of lipophilic cationic toxic compounds from the interior of the hepatocyte to the bile is mediated by P-Glycoprotein. It is an integral protein located in the bile canaliculi. The present work study the hepatic expression of P-Glycoprotein in different models of experimental liver disease Acute paracetamol intoxication, extrahepatic cholestasis and cholestasis followed by acute paracetamol intoxication. mRNA was isolated from liver tissue, and the expression of Pg-p was assessed by Northern blot. It is concluded that the hepatic expression of mdr1b is increased in the experimental liver diseases when compared to controls. On the other hand, mdr2 expression was similar between the different groups
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Index:
LILACS (Americas)
Main subject:
Cholestasis, Extrahepatic
/
Gene Expression Regulation
/
ATP Binding Cassette Transporter, Subfamily B, Member 1
/
Analgesics, Non-Narcotic
/
Genes, MDR
/
Liver Diseases
/
Acetaminophen
Limits:
Animals
Language:
Spanish
Journal:
Acta gastroenterol. latinoam
Journal subject:
Gastroenterology
Year:
2002
Type:
Article
Affiliation country:
Argentina
Institution/Affiliation country:
Universidad de Buenos Aires/AR
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