Molecular epidemiology of HIV-1 in Rio Grande, RS, Brazil
Rev. Soc. Bras. Med. Trop
;
35(5): 471-476, Sept.-Oct. 2002. tab
Article
in English
| LILACS
| ID: lil-327997
ABSTRACT
We conducted a molecular epidemiological study to investigate HIV-1 strains in Rio Grande, southern Brazil, searching for an association with transmission mode and risk behavior. Patients (185) identified at an AIDS treatment reference Hospital, from 1994 to 1997, were included; from which 107 blood samples were obtained. Nested PCR was realized once for each sample; for amplified samples (69) HIV subtypes were classified using the heteroduplex mobility assay. Subtypes identified were B (75 percent), C (22 percent) and F (3 percent). All infections with C were diagnosed after 1994. Comparing patients with B and C, no differences were detected regarding demographic, clinical and laboratory characteristics; survival analysis did not reveal differences in HIV to AIDS evolution. A higher proportion of injecting drug users, IDU (not significant, p<.07) was found among those with C. This suggests that C may have been introduced in this area through IDU, and is being spread, probably by their sexual partners, to persons with other risk practices
Full text:
Available
Index:
LILACS (Americas)
Main subject:
DNA, Viral
/
Acquired Immunodeficiency Syndrome
/
HIV-1
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
/
Screening study
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Rev. Soc. Bras. Med. Trop
Journal subject:
Tropical Medicine
Year:
2002
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Fundaçäo Universidade Federal do Rio Grande/BR
/
Universidade Federal de Minas Gerais/BR
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