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Insuficiência mitral crônica oligossintomática. Análise da funçäo sistólica do ventrículo esquerdo e da fraçäo regurgitante mitral sob açäo farmacológica. Estudo ecocardiográfico / Mildly symptomatic chronic mitral regurgitation. Analysis of left ventricular systolic function and mitral regurgitant fraction under pharmacological influence. Echocardiographic study echocardiographic study
Rivera, Ivan Romero; Moisés, Valdir Ambrósio; Carvalho, Antonio Carlos; Paola, Angelo Amato V. de.
  • Rivera, Ivan Romero; UNIFESP. Escola Paulista de Medicina. Säo Paulo. BR
  • Moisés, Valdir Ambrósio; UNIFESP. Escola Paulista de Medicina. Säo Paulo. BR
  • Carvalho, Antonio Carlos; UNIFESP. Escola Paulista de Medicina. Säo Paulo. BR
  • Paola, Angelo Amato V. de; UNIFESP. Escola Paulista de Medicina. Säo Paulo. BR
Arq. bras. cardiol ; 80(2): 138-149, Feb. 2003. tab
Article in Portuguese, English | LILACS | ID: lil-329093
RESUMO

OBJECTIVE:

To study echocardiographic parameters of left ventricular systolic function and valvar regurgitation under pharmacological influence in mildly symptomatic patients with chronic mitral regurgitation (MR).

METHODS:

We carried out a double-blind placebo controlled study in 12 patients with MR, mean aged 12.5 years old, who were randomized in 4 phases A) digoxin; B) enalapril; C) digoxin + enalapril; D) placebo. The medication was administered for 30 days in each phase, and the following variables were analyzed shortening and ejection fractions, wall stress index of left ventricle, left ventricular meridional end-systolic wall stress, Doppler-derived mean rate of left ventricular pressure rise (mean dP/dt), stroke volume and MR jet area. The clinical variables analysed were heart rate and systemic arterial pressure.

RESULTS:

No significant variation was observed in the clinical variables analysed. The shortening and ejection fraction, the mean dP/dt and stroke volume significantly increased and the wall stress index of left ventricle, the meridional left ventricular end systolic wall stress and the mitral regurgitation jet area decreased in the phases with medication as compared with that in the placebo phase.

CONCLUSION:

The parameters of left ventricular systolic function improved significantly and the degree of MR decreased with the isolated administration of digoxin or enalapril in mildly symptomatic patients with chronic MR. The combination of the drugs, however, did not show better

results:

Subject(s)
Full text: Available Index: LILACS (Americas) Main subject: Ventricular Function, Left / Mitral Valve / Mitral Valve Insufficiency Type of study: Controlled clinical trial / Diagnostic study Limits: Adolescent / Child / Female / Humans / Male Language: English / Portuguese Journal: Arq. bras. cardiol Journal subject: Cardiology Year: 2003 Type: Article Affiliation country: Brazil Institution/Affiliation country: UNIFESP/BR

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Full text: Available Index: LILACS (Americas) Main subject: Ventricular Function, Left / Mitral Valve / Mitral Valve Insufficiency Type of study: Controlled clinical trial / Diagnostic study Limits: Adolescent / Child / Female / Humans / Male Language: English / Portuguese Journal: Arq. bras. cardiol Journal subject: Cardiology Year: 2003 Type: Article Affiliation country: Brazil Institution/Affiliation country: UNIFESP/BR