Technetium-99m nitrido radiopharmaceuticals with unprecedented biological properties
Braz. arch. biol. technol
;
45(spe): 135-142, Sept. 2002. ilus, tab, graf
Article
in English
| LILACS
| ID: lil-329818
ABSTRACT
The chemical methods for the production of technetium-99m radiopharmaceuticals containing a terminal TcFACE="Symbol">ºN triple bond have been established more than a decade ago. From that time, the chemistry of nitrido Tc-99m complexes has provided a highly efficient tool for the design and preparation of novel classes of diagnostic agents, and a number of potentially useful radiopharmaceuticals have been discovered. In particular, nitrido technetium-99m tracers have been developed for heart perfusion imaging. In this short review, the chemical and biological properties of the neutral myocardial perfusion tracer bis(N-ethoxy, N-ethyl-dithiocarbamato) nitrido Tc-99m (TcN-NOEt) will be summarized along with the preparation and preliminary biological evaluation of the first class of monocationic nitrido technetium-99m radiopharmaceuticals exhibiting improved biodistribution properties closer to those expected for an ideal perfusion imaging agent
Full text:
Available
Index:
LILACS (Americas)
Language:
English
Journal:
Braz. arch. biol. technol
Journal subject:
Biology
Year:
2002
Type:
Article
Affiliation country:
Italy
Institution/Affiliation country:
University of Ferrara/IT
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