Insuficiencia suprarrenal secundaria a paracoccidioidomicosis / Adrenal gland insufficiency secondary to paracoccidioidomycosis
Biomédica (Bogotá)
;
22(3): 280-286, sep. 2002.
Article
in Spanish
| LILACS
| ID: lil-330480
ABSTRACT
Paracoccidioidomycosis is regularly associated with adrenal insufficiency in 10-15 of symptomatic cases, and in some instances, diagnosis of the mycosis precedes the adrenal manifestation. To establish the frequency of this association, records were reviewed of 207 cases diagnosed with mycosis at the Mycology Service of the Corporación para Investigaciones Biológicas. Six cases (2.9) were found to have adrenal insufficiency. Patients were all males with a mean age of 67.2 years (range 48-75) and most worked in agriculture. The duration of the symptoms of adrenal damage was 4.1 months (range 2-6). All patients experienced weight loss and malaise; all had abnormal lung X-rays. Major clinical improvement was recorded after initiation of the specific treatments consisting of itraconazole, prednisolone and fluorcortisone. Diminished antibody titers against Paracoccidioides brasiliensis were also recorded after treatment. Prompt treatment re-established adrenal function and effected recovery of normal gland morphology. Consequently, early detection of hypoadrenalism in patients living in the endemic areas is necessary to avoid further adrenal damage and permits a shorter hormonal treatment period in patients afflicted by the mycosis.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Paracoccidioidomycosis
/
Addison Disease
Type of study:
Diagnostic study
/
Screening study
Limits:
Female
/
Humans
/
Male
Language:
Spanish
Journal:
Biomédica (Bogotá)
Journal subject:
Medicine
Year:
2002
Type:
Article
Affiliation country:
Colombia
Institution/Affiliation country:
Corporación para Investigaciones Biológicas/CO
/
Universidad del Valle/CO
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