Interleukin-2 receptor serum concentrations in normal pregnancy and pre-eclampsia
Invest. clín
;
43(2): 73-78, jun. 2002.
Article
in English
| LILACS
| ID: lil-330978
ABSTRACT
The purpose of this research was to assess interleukin-2 receptor serum levels in normal pregnancy and pre-eclampsia. Sera from 90 healthy pregnant women (30 for each trimester), 30 with pre-eclampsia and a group of 30 healthy non-pregnant were analyzed. Soluble interleukin-2 receptor was measured by specific double antibody enzymatic immunoassay (ELISA). Results were 267.5 +/- 12.3 (mean +/- s.e.m) pg/mL in the uncomplicated first trimester sample, 300.9 +/- 14.5 pg/mL in the second trimester and 248.8 +/- 12.5 pg/mL in the third. The non-pregnant control group had 443.7 +/- 39.6 pg/mL, significantly different from normal pregnancy in all trimesters (p < 0.001). The concentration in pre-eclamptic patients was 382.2 +/- 24.2 pg/mL, with p < 0.01 with regard to the normal third trimester group. The conclusion is that interleukin-2 receptor serum levels diminish in normal pregnancy and rise in preeclampsia. The first finding seems to be a protective mechanism to the fetal allograft. The latter, point to increased cellular activity.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Pre-Eclampsia
/
Pregnancy
/
Receptors, Interleukin-1
Limits:
Adolescent
/
Adult
/
Female
/
Humans
Language:
English
Journal:
Invest. clín
Journal subject:
Biologia
/
Medicine
/
Relatos de Casos
Year:
2002
Type:
Article
Affiliation country:
Venezuela
Institution/Affiliation country:
Instituto Venezolano de los Seguros Sociales/VE
/
Universidad del Zulia/VE
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