Alteración de la respuesta inmunológica sistémica en asociación con endometriosis, empleando un modelo de estudio animal / Changes in the systemic immunologic response in association with endometriosis using an animal model
Ginecol. obstet. Méx
;
70(4): 171-181, abr. 2002.
Article
in Spanish
| LILACS
| ID: lil-331102
RESUMO
INTRODUCTION: Endometriosis constitutes the growth of endometrial tissue in a place other than the uterine cavity. Its etiopathogenesis is unknown, although there is some evidence associating it with the decrease of cytotoxic activity in the immunological system. OBJECTIVE: Evaluating the relationship between the development of ectopic endometrial tissue and the immunological status, and enumerating lymphocyte subpopulations and cytokine synthesis in T lymphocytes, using a murine endometriosis model. METHODOLOGY: Spleen lymphocytes isolated from two study groups of 10 female mice of the Balb/c strain that had been submitted to the surgical implantation of autologous endometrial tissue in the peritoneal cavity, and sacrificed after 5 (group I) and 8 (group II) weeks, were incubated--or not--with PMA/lonomicine. Lymphocyte T numbers and their cytokine production were determined by flow cytometry. RESULTS: A lower dispersion of the ectopic tissue growth value was observed in group II (24 vs. 42). A smaller population of cytotoxic T lymphocytes and a greater IL-4 production in the stimulated cells of the study group (p < 0.05) were observed, as compared to the control group. CONCLUSIONS: The presence of endometrial tissue in the uterine cavity decreases the amount of cytotoxic T lymphocytes and increases IL-4 production in total T lymphocytes, suggesting a modulation of the systemic immunological response to TH-2.
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Index:
LILACS (Americas)
Main subject:
T-Lymphocytes
/
T-Lymphocyte Subsets
/
Interleukins
/
Interferon-gamma
/
Endometriosis
Type of study:
Prognostic study
/
Risk factors
Limits:
Animals
Language:
Spanish
Journal:
Ginecol. obstet. Méx
Journal subject:
Gynecology
/
Obstetrics
Year:
2002
Type:
Article
Affiliation country:
Mexico
Institution/Affiliation country:
Instituto Nacional de Perinatología/MX
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