Stress regulates the lymphocyte homing receptor CD62L (L-selectin)
Arq. neuropsiquiatr
;
61(1): 20-24, mar. 2003. graf
Article
in English
| LILACS
| ID: lil-331153
RESUMO
Based on a previous study showing that panic disorder patients had increased expression of naïve phenotype lymphocytes (CD45RA+ and CD62L+), increased plasma cortisol, as well as decreased interleukin-2 (IL-2) producion, we hypothesized that changes in the percentage of expression of these lymphocyte surface molecules could be related to the substances released by the hypothalamic-pituitary-adrenal (HPA) axis and possibly associated to panic disorder (cortisol, IL-2, serotonin and epinephrine). In order to study the altered expression, blood mononuclear cells of normal volunteers were stimulated with mitogen, in the presence of dexamethasone, IL-2, serotonin and epinephrin. CD62L is decreased by IL-2 in vitro. Serotonin and epinephrine did not promote changes in the expression of these surface molecules. The results of the ex vivo study are in agreement with a previous clinical study with panic patients. It could be suggested that stress is responsible for certain immunologic dysfunctions and new studies should be conducted
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Stress, Psychological
/
In Vitro Techniques
/
Dexamethasone
/
T-Lymphocytes
/
Epinephrine
/
Panic Disorder
/
L-Selectin
Type of study:
Observational study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Arq. neuropsiquiatr
Journal subject:
Neurology
/
Psychiatry
Year:
2003
Type:
Article
Affiliation country:
Brazil
/
United States
Institution/Affiliation country:
Harvard Medical School/US
/
Universidade Federal do Rio Grande do Sul/BR
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