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A novel reiterated family of transcribed oligo(A)-terminated, interspersed DNA elements in the genome of Trypanosoma cruzi
Verbisck, Newton Valério; Santos, Márcia Regina Machado dos; Engman, David M; Angel Chiurillo, Miguel; Ramirez, José Luis; Araya, Jorge Enrique; Mortara, Renato Arruda; Silveira, José Franco da.
  • Verbisck, Newton Valério; Escola Paulista de Medicina. Departamento de Microbiologia, Imunologia e Parasitologia. São Paulo. BR
  • Santos, Márcia Regina Machado dos; Escola Paulista de Medicina. Departamento de Microbiologia, Imunologia e Parasitologia. São Paulo. BR
  • Engman, David M; Northwestern University Medical School. Departments of Pathology and Microbiology-Immunology. Chigago. US
  • Angel Chiurillo, Miguel; Universidad Central de Venezuela. Instituto de Biologia Experimental. Laboratorio de Genetica Molecular. Caracas. VE
  • Ramirez, José Luis; Universidad Central de Venezuela. Instituto de Biologia Experimental. Laboratorio de Genetica Molecular. Caracas. VE
  • Araya, Jorge Enrique; Universidad de Antofagasta. Departamento de Tecnologia Médica. Antofagasta. CL
  • Mortara, Renato Arruda; Escola Paulista de Medicina. Departamento de Microbiologia, Imunologia e Parasitologia. São Paulo. BR
  • Silveira, José Franco da; Escola Paulista de Medicina. Departamento de Microbiologia, Imunologia e Parasitologia. São Paulo. BR
Mem. Inst. Oswaldo Cruz ; 98(1): 129-133, Jan. 30, 2003. ilus
Article in English | LILACS | ID: lil-331390
ABSTRACT
We report the molecular characterization of a novel reiterated family of transcribed oligo(A)-terminated, interspersed DNA elements in the genome of Trypanosoma cruzi. Steady-state level of transcripts of this sequence family appeared to be developmentally regulated, since only in the replicative forms the parasite showed expression of related sequences with a major band around 3 kb. The presence of frame shifts or premature stop codons predicts that transcripts are not translated. The sequence family also contains truncated forms of retrotransposons elements that may become potential hot spots for retroelement insertion. Sequences homologous to this family are interspersed at many chromosomes including the subtelomeric regions
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Full text: Available Index: LILACS (Americas) Main subject: Trypanosoma cruzi / DNA, Protozoan / Genome, Protozoan / Interspersed Repetitive Sequences Limits: Animals Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2003 Type: Article / Project document Affiliation country: Brazil / Chile / United States / Venezuela Institution/Affiliation country: Escola Paulista de Medicina/BR / Northwestern University Medical School/US / Universidad Central de Venezuela/VE / Universidad de Antofagasta/CL

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Full text: Available Index: LILACS (Americas) Main subject: Trypanosoma cruzi / DNA, Protozoan / Genome, Protozoan / Interspersed Repetitive Sequences Limits: Animals Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2003 Type: Article / Project document Affiliation country: Brazil / Chile / United States / Venezuela Institution/Affiliation country: Escola Paulista de Medicina/BR / Northwestern University Medical School/US / Universidad Central de Venezuela/VE / Universidad de Antofagasta/CL