High frequency of skin reactions in patients with leishmaniasis treated with meglumine antimoniate contaminated with heavy metals. A comparative approach using historical controls
Mem. Inst. Oswaldo Cruz
;
98(1): 145-149, Jan. 30, 2003. tab
Article
in English
| LILACS
| ID: lil-331393
ABSTRACT
We analyzed data from historical controls treated with meglumine antimoniate to compare the frequency of adverse events observed in patients with cutaneous leishmaniasis treated with the same dose of meglumine antimoniate contaminated with heavy metals in an endemic area of the State of Bahia, Brazil. Group A patients were treated in 2000 with the drug produced by Eurofarma Laboratórios Ltda., São Paulo, Brazil (lot A) and group B patients were treated in 1996 with the reference drug produced by Rhodia Farma Ltda., São Paulo, Brazil (lot B). We observed an unusual higher frequency of skin reactions in group A patients. However, all type of adverse events observed in group A were also observed in group B. The physico-chemical analysis of these lots revealed that lot A had lower pH and higher concentration of total and trivalent antimony, lead, cadmium, and arsenic. Our findings suggest that the skin reactions could be attributed to heavy metal contamination of lot A
Full text:
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Index:
LILACS (Americas)
Main subject:
Organometallic Compounds
/
Arsenic
/
Leishmaniasis, Cutaneous
/
Metals, Heavy
/
Meglumine
/
Antiprotozoal Agents
Type of study:
Observational study
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2003
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal de Santa Maria/BR
/
Universidade de Brasília/BR
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