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Histometric study of socket healing after tooth extraction in rats treated with diclofenac
Yugoshi, Luciana Ibara; Sala, Miguel Angel; Brentegani, Luiz Guilherme; Carvalho, Teresa Lúcia Lamano.
  • Yugoshi, Luciana Ibara; University of São Paulo. Faculty of Dentistry of Ribeirão Preto. Department of Morphology, Stomatology and Physiology. BR
  • Sala, Miguel Angel; University of São Paulo. Faculty of Dentistry of Ribeirão Preto. Department of Morphology, Stomatology and Physiology. BR
  • Brentegani, Luiz Guilherme; University of São Paulo. Faculty of Dentistry of Ribeirão Preto. Department of Morphology, Stomatology and Physiology. BR
  • Carvalho, Teresa Lúcia Lamano; University of São Paulo. Faculty of Dentistry of Ribeirão Preto. Department of Morphology, Stomatology and Physiology. BR
Braz. dent. j ; 13(2): 92-96, 2002.
Article in English | LILACS | ID: lil-332154
ABSTRACT
The purpose of the present study was to investigate if diclofenac administration interferes with the time course of alveolar wound healing in rats. Forty-two Wistar rats were used, 21 rats received 10 mg/kg/day of diclofenac one day before and 4 days after extraction of the right maxillary incisors and 21 rats received saline. The animals were sacrificed 7, 14 and 21 days after tooth extraction. Progressive new bone formation and a decrease in the volume fraction of blood clot and connective tissue from 1 to 3 weeks after tooth extraction was quantified using the histometric point-counting method. Diclofenac treatment caused a significant delay in new bone formation in association with an impairment of blood clot remission/organization.
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Full text: Available Index: LILACS (Americas) Main subject: Tooth Extraction / Anti-Inflammatory Agents, Non-Steroidal / Diclofenac / Tooth Socket Limits: Animals Language: English Journal: Braz. dent. j Journal subject: Dentistry Year: 2002 Type: Article Affiliation country: Brazil Institution/Affiliation country: University of São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Tooth Extraction / Anti-Inflammatory Agents, Non-Steroidal / Diclofenac / Tooth Socket Limits: Animals Language: English Journal: Braz. dent. j Journal subject: Dentistry Year: 2002 Type: Article Affiliation country: Brazil Institution/Affiliation country: University of São Paulo/BR