In vitro evaluation of verapamil and other modulating agents in Brazilian chloroquine-resistant Plasmodium falciparum isolates
Rev. Soc. Bras. Med. Trop
;
36(1): 5-9, jan.-fev. 2003. ilus, tab, graf
Article
in English
| LILACS, SES-SP
| ID: lil-332882
RESUMO
Verapamil, was assayed to record its modulating effect upon Brazilian Plasmodium falciparum isolates resistant to chloroquine. Other cardiovascular drugs known to be modulating agents in resistant malaria and/or multidrug-resistant neoplasias, including nifedipine, nitrendipine, diltiazem and propranolol, were also evaluated. Concentrations similar to those for cardiovascular therapy were used in the in vitro microtechnique for antimalarial drug susceptibility. Intrinsic antiplasmodial activity was observed from the lowest concentrations without a significant modulating action. Other reported modulating agents, such as the antipsychotic drug trifluoperazine and the antidepressants desipramine and imipramine, demonstrated similar responses under the same experimental conditions. Results suggest a much higher susceptibility of Brazilian strains, as well as an indifferent behaviour in relation to modulating agents
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Plasmodium falciparum
/
Calcium Channel Blockers
/
Verapamil
/
Chloroquine
/
Antimalarials
Limits:
Animals
/
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Rev. Soc. Bras. Med. Trop
Year:
2003
Type:
Article
Institution/Affiliation country:
Superintendência de Controle de Endemias/BR
/
Universidade de São Paulo/BR
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