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The feasibility of a porcine model of acute coronary occlusion and reperfusion using off-pump coronary artery bypass grafting
Brann, S. H; Thomas, C. N; Rose, S. S; Harperm, T; Chen, D; Ezeokoli, C; Cummings, P; Daniel, S.
  • Brann, S. H; University of the West Indies. Eric Williams Medical Sciences Complex. Cardiopulmonary Research Unit. TT
  • Thomas, C. N; University of the West Indies. Eric Williams Medical Sciences Complex. Cardiopulmonary Research Unit. TT
  • Rose, S. S; University of the West Indies. Eric Williams Medical Sciences Complex. Cardiopulmonary Research Unit. TT
  • Harperm, T; University of the West Indies. Eric Williams Medical Sciences Complex. Cardiopulmonary Research Unit. TT
  • Chen, D; University of the West Indies. Eric Williams Medical Sciences Complex. Cardiopulmonary Research Unit. TT
  • Ezeokoli, C; University of the West Indies. Eric Williams Medical Sciences Complex. Cardiopulmonary Research Unit. TT
  • Cummings, P; University of the West Indies. Eric Williams Medical Sciences Complex. Cardiopulmonary Research Unit. TT
  • Daniel, S; University of the West Indies. Eric Williams Medical Sciences Complex. Cardiopulmonary Research Unit. TT
West Indian med. j ; 49(4): 271-275, Dec. 2000.
Article in English | LILACS | ID: lil-333445
ABSTRACT
We developed an open-chest porcine model of acute coronary occlusion and surgical reperfusion, and attempted to prevent intra-operative ischaemic ventricular fibrillation (VF) by a Retrograde Intracoronary Glyceryl trinitrate (RIG) infusion into the occluded vessel. Five Yorkshire pigs (weight 50 +/- 1.1 kg), randomized into 3 groups, underwent median sternotomy under general anaesthesia. One pig (Group 1, control) underwent sternotomy and pericardiotomy only. Four pigs underwent acute left anterior descending (LAD) coronary occlusion. Two pigs were not reperfused (Group 2). Two pigs underwent surgical reperfusion (Group 3) via left internal mammary artery (LIMA) grafting to the LAD using the Off-Pump Coronary Artery Bypass (OPCAB) technique. Ischaemic injury was assessed using 7-lead electrocardiography (ECG) and transthoracic/epimyocardial echocardiography (ECHO). Group 1 transient intraoperative hypotension and VF occurred. Successful resuscitation and 10-week survival (until sacrifice) with normal left ventricular (LV) function was achieved. Group 2 there were ECG and ECHO evidence of acute LV ischaemic dysfunction in both pigs. The surviving pig had persistent anterior hypokinesis at 8 1/2 months. The other died intra-operatively following progressive ischaemic LV dysfunction despite resuscitative attempts. Group 3 the surviving pig had normal LV function at 8 months. Initial anterior LV akinesis normalized within 7 days. The other developed post-occlusion haemodynamic instability and died intra-operatively despite reperfusion. In this porcine model, acute LAD artery occlusion modified by the novel RIG infusion technique, followed by surgical reperfusion (OPCAB) is feasible. This model would facilitate further development of OPCAB surgical expertise and understanding of the pathophysiology of ischaemia-reperfusion injury.
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Index: LILACS (Americas) Main subject: Swine / Myocardial Reperfusion Injury / Coronary Disease / Disease Models, Animal / Internal Mammary-Coronary Artery Anastomosis Type of study: Controlled clinical trial Limits: Animals / Humans Language: English Journal: West Indian med. j Journal subject: Medicine Year: 2000 Type: Article Affiliation country: Trinidad and Tobago Institution/Affiliation country: University of the West Indies/TT

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Index: LILACS (Americas) Main subject: Swine / Myocardial Reperfusion Injury / Coronary Disease / Disease Models, Animal / Internal Mammary-Coronary Artery Anastomosis Type of study: Controlled clinical trial Limits: Animals / Humans Language: English Journal: West Indian med. j Journal subject: Medicine Year: 2000 Type: Article Affiliation country: Trinidad and Tobago Institution/Affiliation country: University of the West Indies/TT