Anticuerpos neutralizantes frente a 5 cepas de VIH-1 en macacos inmunizados con el polipéptido multiepitópico TAB9 / Neutralizing antibodies to 5 HIV-1 strains in macaques immunized with the multi-epitope polypeptide TAB9
Rev. cuba. med. trop
;
52(2): 115-118, May-Aug. 2000.
Article
in Spanish
| LILACS
| ID: lil-333486
RESUMO
Presence of neutralizing antibodies(Nab) to 5 laboratory strains of human immunodeficiency virus type-1 (HIV-1) was studied and compared in the sera of eight macaca (Macaca fascicularis) after the third and fourth immunizations with multi-epitope polypeptide TAB9, emulsified with adjuvant Montanide ISA 720. Four animals were inoculated 1 mg and the others 200 micrograms, 2 animals were used as controls and injected only with adjuvant. Although the presence of neutralizing antibodies to homologous strains of HIV-group group B was confirmed in most animals after immunization through antigen p24 capture ELISA (DAVIH-Agp24, Cuba), no statistically significant differences were found neither in titers caused by antigen concentrations nor in the responses after the third and fourth immunizing doses. Controls did not develop neutralizing antibodies.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Recombinant Fusion Proteins
/
HIV Antibodies
/
HIV Antigens
/
HIV-1
/
Epitopes
Limits:
Animals
Language:
Spanish
Journal:
Rev. cuba. med. trop
Journal subject:
Tropical Medicine
Year:
2000
Type:
Article
Affiliation country:
Cuba
Institution/Affiliation country:
Centro de Investigaciones Científicas de la Defensa Civil/CU
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