Mecanismos celulares y bioquímicos involucrados en la fisiopatogenia de la púrpura trombocitopénica autoinmune / Cellular and biochemical mechanisms involved in physiopathogenesis of autoimmune thrombocytopenic purpura
Gac. méd. Méx
;
138(5): 461-472, sep.-oct. 2002.
Article
in Spanish
| LILACS
| ID: lil-333690
RESUMO
Autoimmune thrombocytopenic purpura (ATP) is a bleeding disorder caused by excessive destruction of antibody-coated platelets. It is known that platelet destruction takes place in macrophages of reticulo-endothelial system, but immunological mechanisms involved in such destruction are unknown. The objective of this article is to review the literature concerning pathogenesis of ATP to have controlled experimental conditions some animal laboratory models have been used. The (NZW X BXSB) F1 mice have been studied as autoimmune disease model and Harrington mouse as an immune purpura model. Studies in humans suggest that there are some differences in pathogenesis of acute or chronic ATP, particularly in reactive T cells. For example, in chronic form there are high levels of The (CD4+) activity concomitant with low levels of T suppressor (CD8+) activity, while in acute form there is no dominance of any particular T cell activity or CD4+ is even decreased. Mitogen lymphocyte proliferation is increased in chronic ATP but decreased in acute form.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Purpura, Thrombocytopenic, Idiopathic
Limits:
Animals
/
Humans
Language:
Spanish
Journal:
Gac. méd. Méx
Journal subject:
Medicine
Year:
2002
Type:
Article
Affiliation country:
Mexico
Institution/Affiliation country:
Centro Nacional de la Transfusión Sanguínea/MX
/
UNAM/MX
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