El receptor "pepenador" y su importancia en procesos amiloidáticos / The scavenger receptor and its importance in amyloid processes
Gac. méd. Méx
;
138(5): 445-460, sep.-oct. 2002.
Article
in Spanish
| LILACS
| ID: lil-333691
RESUMO
The scavenger receptor (SRA or RPA) belongs to a wide family of receptor proteins. The classification is based on sequence homologies and structural similarities; nevertheless, it has been useful to group them on the basis of ligand specificity. The SRA was first identified as a receptor for modified low-density lipoproteins, where such modification permits to regulate the uptake of modified LDL by macrophages leading to a massive cholesterol accumulation. Moreover, SRA facilitates the clearance by phagocytic cells of microbial pathogens and senescent cells. SRA is a transmembrane glycoprotein that exists as a trimer comprised of a cystein-linker dimer and a non-covalently bound monomer. SRA has an a-helical coiled coil domain, which is essential for both trimer formation and acid-dependent ligand dissociation. It also contains a collagenous domain, essential for ligand binding. The majority of these ligands are polyanionic molecules, such as the A beta-peptide, important in the development of Alzheimer's disease. Present findings including our own consider that binding of these peptides to SRA activates an inflammatory response with the production of oxidative stress.
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Index:
LILACS (Americas)
Main subject:
Receptors, Immunologic
/
Amyloidosis
Type of study:
Etiology study
/
Prognostic study
Limits:
Humans
Language:
Spanish
Journal:
Gac. méd. Méx
Journal subject:
Medicine
Year:
2002
Type:
Article
Affiliation country:
Mexico
Institution/Affiliation country:
UNAM/MX
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