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Anti-human immunodeficiency virus-1 antibody titers in injection drug users compared to sexually infected individuals
Bongertz, Vera; Ouverney, Elaine Priscilla; Teixeira, Sylvia L. M; Silva-de-Jesus, Carlos; Hacker, Mariana A; Morgado, Mariza G; Bastos, Francisco I.
  • Bongertz, Vera; Fiocruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Aids e Imunologia Molecular. Rio de Janeiro. BR
  • Ouverney, Elaine Priscilla; Fiocruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Aids e Imunologia Molecular. Rio de Janeiro. BR
  • Teixeira, Sylvia L. M; Fiocruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Aids e Imunologia Molecular. Rio de Janeiro. BR
  • Silva-de-Jesus, Carlos; Fiocruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Aids e Imunologia Molecular. Rio de Janeiro. BR
  • Hacker, Mariana A; Fiocruz. Centro de Informações em Ciência e Tecnologia. Rio de Janeiro. BR
  • Morgado, Mariza G; Fiocruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Aids e Imunologia Molecular. Rio de Janeiro. BR
  • Bastos, Francisco I; Fiocruz. Centro de Informações em Ciência e Tecnologia. Rio de Janeiro. BR
Mem. Inst. Oswaldo Cruz ; 98(2): 209-212, Mar. 15, 2003. tab, graf
Article in English | LILACS | ID: lil-334256
ABSTRACT
Sera from infected injection drug users (IDU) have shown to have antibodies against synthetic human immunodeficiency virus-1 (HIV-1) envelope peptides more frequently. In this study, reactivity of 48 IDU plasma were compared to 60 plasmas obtained from sexually infected individuals (S). The overall reactivity of plasma from IDU compared to S was higher, and the reactivity titers were much higher for IDU plasma than S. IDU plasma also showed a broader antibody response. The higher reactivity titers were observed mainly for the gp41 immunodominant epitope and V3 peptides corresponding to the consensus sequences of HIV-1 subtypes/variants prevalent in Brazil (B, F, C) indicating the specificity in the higher immune response of IDU
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Full text: Available Index: LILACS (Americas) Main subject: Peptide Fragments / HIV Antibodies / HIV Envelope Protein gp41 / HIV Envelope Protein gp120 / HIV Infections / HIV-1 Type of study: Prognostic study Limits: Female / Humans / Male Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2003 Type: Article Affiliation country: Brazil Institution/Affiliation country: Fiocruz/BR

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Full text: Available Index: LILACS (Americas) Main subject: Peptide Fragments / HIV Antibodies / HIV Envelope Protein gp41 / HIV Envelope Protein gp120 / HIV Infections / HIV-1 Type of study: Prognostic study Limits: Female / Humans / Male Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2003 Type: Article Affiliation country: Brazil Institution/Affiliation country: Fiocruz/BR