Neogénesis y regeneración de las células beta pancreáticas / Pancreatic beta-cell neogenesis and regeneration
Gac. méd. Méx
;
138(6): 557-564, Nov.-Dec. 2002.
Article
in Spanish
| LILACS
| ID: lil-334526
ABSTRACT
OBJECTIVE:
To review the literature on beta-cell neogenesis and regeneration, with special interest in substances that regulate such processes.DESIGN:
Representative papers were selected through a computer MEDLINE search from 1990 to 2000.RESULTS:
Several studies showed that once islets of Langerhans developed from small pancreatic ducts, this process did not continue in normal adult individuals. However, it has been published that new beta-cell formation can occur in vivo in certain experimental models through neogenesis, in which gene pax 4 is extremely important. On the other hand, substances that stimulate the regenerative process of beta-cells include glucose, several hormones and certain growth factors.CONCLUSIONS:
Substances that stimulate the regenerative process commonly express this effect in elevated, non-physiologic concentrations; thus, their possible therapeutic importance is not yet clear. Nevertheless, the Reg protein, present in regenerative pancreas and implied in neogenesis process, has actual possibilities of becoming therapeutically important.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Islets of Langerhans
Type of study:
Prognostic study
Limits:
Animals
/
Humans
Language:
Spanish
Journal:
Gac. méd. Méx
Journal subject:
Medicine
Year:
2002
Type:
Article
Affiliation country:
Mexico
Institution/Affiliation country:
Instituto Mexicano del Seguro Social/MX
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