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Neogénesis y regeneración de las células beta pancreáticas / Pancreatic beta-cell neogenesis and regeneration
Haro-Hernández, Roberto de; Méndez, José D.
  • Haro-Hernández, Roberto de; Instituto Mexicano del Seguro Social. Centro Médico Nacional Siglo XXI. Hospital de Especialidades. MX
  • Méndez, José D; Instituto Mexicano del Seguro Social. Centro Médico Nacional Siglo XXI. Hospital de Especialidades. MX
Gac. méd. Méx ; 138(6): 557-564, Nov.-Dec. 2002.
Article in Spanish | LILACS | ID: lil-334526
ABSTRACT

OBJECTIVE:

To review the literature on beta-cell neogenesis and regeneration, with special interest in substances that regulate such processes.

DESIGN:

Representative papers were selected through a computer MEDLINE search from 1990 to 2000.

RESULTS:

Several studies showed that once islets of Langerhans developed from small pancreatic ducts, this process did not continue in normal adult individuals. However, it has been published that new beta-cell formation can occur in vivo in certain experimental models through neogenesis, in which gene pax 4 is extremely important. On the other hand, substances that stimulate the regenerative process of beta-cells include glucose, several hormones and certain growth factors.

CONCLUSIONS:

Substances that stimulate the regenerative process commonly express this effect in elevated, non-physiologic concentrations; thus, their possible therapeutic importance is not yet clear. Nevertheless, the Reg protein, present in regenerative pancreas and implied in neogenesis process, has actual possibilities of becoming therapeutically important.
Subject(s)
Full text: Available Index: LILACS (Americas) Main subject: Islets of Langerhans Type of study: Prognostic study Limits: Animals / Humans Language: Spanish Journal: Gac. méd. Méx Journal subject: Medicine Year: 2002 Type: Article Affiliation country: Mexico Institution/Affiliation country: Instituto Mexicano del Seguro Social/MX

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Full text: Available Index: LILACS (Americas) Main subject: Islets of Langerhans Type of study: Prognostic study Limits: Animals / Humans Language: Spanish Journal: Gac. méd. Méx Journal subject: Medicine Year: 2002 Type: Article Affiliation country: Mexico Institution/Affiliation country: Instituto Mexicano del Seguro Social/MX