C cells in the thyroid of pinealectomized rats
Rev. Hosp. Clin. Fac. Med. Univ. Säo Paulo
;
58(1): 21-26, Jan.-Feb. 2003. ilus, tab
Article
in English
| LILACS
| ID: lil-335226
RESUMO
PURPOSE:
To study quantitatively C cells in the thyroids of non-isogenic rats to determine the possible effects of pinealectomy on the number of these cells, and consequently on the synthesis and secretion of calcitonin.METHODS:
Twenty male rats of an outbred strain (200-300 g) were used in the present study. One group of 10 animals was pinealectomized 50 days prior to sacrifice. Thyroid tissue was stained for calcitonin (Dako Corporation) at a 11500 dilution. The number of C cells observed was expressed as number of cells/cm². Data were analyzed statistically by Mann-Whitney test.RESULTS:
The number of C cells in pinealectomized and normal animals ranged from 489 to 2084 per cm² and 227 to 1584 per cm², respectively, a difference that was statistically significant (P <0.05).CONCLUSIONS:
These results showed consistent differences in the number of C cells after pinealectomy when compared to controls. We believe that pinealectomy increases the number of C cells in the rat thyroid
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Pineal Gland
/
Thyroid Gland
/
Calcitonin
Limits:
Animals
Language:
English
Journal:
Rev. Hosp. Clin. Fac. Med. Univ. Säo Paulo
Journal subject:
Medicine
Year:
2003
Type:
Article
/
Project document
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