Calcium- and zinc-binding proteins in intracellular transport
Biocell
;
20(3): 339-342, Dec. 1996.
Article
in English
| LILACS
| ID: lil-335982
RESUMO
The complex mechanism of intracellular transport is regulated by free calcium in different manners. Calcium binding proteins regulate several aspects of the vesicle fusion mechanism mediated by NSF (N-ethylmaleimide sensitive fusion factor). At least in some regulated exocytosis, calcium-binding proteins are the trigger for fusion downstream of NSF, Still, calcium-binding proteins, such as annexins, may be part of a different fusion mechanism mediating some specific transport steps or working in parallel to the NSF-dependent fusion process. Calcium is not the only ion necessary for the function of factors involved in vesicular transport. A zinc requirement has been also proposed. One of the zinc-dependent factors is probably a protein with a cysteine-rich region that coordinates zinc and binds phorbol esters. Although protein kinase C is the more prominent family of proteins carrying this domain, the factor necessary for transport does not appear to function as a kinase.
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Index:
LILACS (Americas)
Main subject:
Zinc
/
Biological Transport
/
Calcium-Binding Proteins
/
Calcium
/
Metalloproteins
Limits:
Animals
Language:
English
Journal:
Biocell
Journal subject:
Clulas
Year:
1996
Type:
Article
Affiliation country:
Argentina
Institution/Affiliation country:
Universidad Nacional de Cuyo/AR
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