Retrospective review and systematic study of mammary tumors in dogs and characteristics of the extracellular matrix

RESUMO

The aim of the present study was to perform a retrospective review, from 1932 to 1999, in order to establish the number of cases of mammary tumors in dogs in the records at the Pathology Department of Faculdade de Medicina Veterinária - USP, as well as the presence of desmoplasia and cartilaginous and bone metaplasia in 578 of these tumors. Among the 537 malignant tumors, 13.05 percent were simple tubular adenocarcinomas, 3.91 percent were complex tubular adenocarcinomas, 7.26 percent simple papillary adenocarcinomas, 4.28 percent complex papillary adenocarcinomas , 23.27 percent simple papillary cystadenocarcinomas ,8.37 percent complex papillary cystadenocarcinomas,16.38 percent simple solid adenocarcinomas ,6.70 percent complex solid adenocarcinomas, 2.04 percent simple spindle cell carcinomas, 1.11 percent simple spindle cell carcinomas ,2.79 percent mucinous carcinomas ,8.19 percent anaplastic carcinomas ,0.93 percent squamous carcinomas, 1.30 percent fibrosarcomas,.0.18 percent chondrosarcoma, 0.18 percent osteosarcoma and among the 41 benign tumors ,51.21 percent were adenoma, 12.19 percent papillary cystadenoma,7.31 percent papilloma, 4.87 percent cystic fibroadenoma and 24.39 percent were fibroadenoma. Both desmoplasia and metaplasia were frequent findings in benign and malignant neoplasms, but they were more frequent among complex tubular adenocarcinomas 38 percent presented desmoplasia, 57 percent cartilaginous metaplasia and 28 percent bone metaplasia. Among the benign neoplasms, adenoma presented the more frequency 14 percent presented desmoplasia, 29 percent cartilaginous metaplasia and 24 percent bone metaplasia. Results of this study emphasize the complexity of the inter-relationship between the macromolecules in the extracellular matrix and tumoral cells