Efecto de la hidroxiurea en hemoglobina S / Effect of hydroxyurea on hemoglobin S
Medicina (B.Aires)
;
63(2): 140-142, 2003. tab
Article
in Spanish
| LILACS
| ID: lil-338579
ABSTRACT
Previous studies have determined the laboratory alterations, clinical efficacy and toxicity profile associated with hydroxyurea (HU) therapy in patients with severe sickle cell anemia. We report the efficacy of HU treatment in the prevention of vaso-occlusive crises in an 11-years-old boy with severe sickle cell disease. The number of vaso-occlusive crises, hospital days and blood transfusions in the year before HU treatment were compared with the same parameters at 6, 12, 24, 36 and 72 months of treatment. A decrease in the frequency of vaso-occlusive crises, blood transfusions and days spent in hospital were demonstrated during the HU treatment period compared to the same period before hand. The clinical and laboratory response to HU was dramatic in this severely affected patient, allowing him a normal schooling and social life. The adverse effects observed were not serious and reversed after transient discontinuation of HU. We conclude that long-term chronic treatment with HU for seriously ill sickle cell patients appears feasible, and devoid of any major toxicity
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Arterial Occlusive Diseases
/
Hemoglobin, Sickle
/
Hydroxyurea
/
Anemia, Sickle Cell
/
Antisickling Agents
Limits:
Child
/
Humans
/
Male
Language:
Spanish
Journal:
Medicina (B.Aires)
Journal subject:
Medicine
Year:
2003
Type:
Article
Affiliation country:
Argentina
Institution/Affiliation country:
Hospital de Pediatría Juan P. Garrahan/AR
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