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Functional dyspepsia: relationship between clinical subgroups and Helicobacter pylori status in Western Turkey
Saruc, M; Ozden, N; Turkel, N; Ayhan, S; Demir, M. A; Tuzcuoglu, I; Akarca, U. S; Yuceyar, H.
  • Saruc, M; University of Nebraska Medical Center. Eppley Cancer Research Institute. Omaha. US
  • Ozden, N; Celal Bayar University. Department of Pathology. Manisa. TR
  • Turkel, N; Celal Bayar University. Department of Gastroenterology. Manisa. TR
  • Ayhan, S; University of Nebraska Medical Center. Division of Gastroenterology and Hepatology. Omaha. US
  • Demir, M. A; University of Nebraska Medical Center. Division of Gastroenterology and Hepatology. Omaha. US
  • Tuzcuoglu, I; Celal Bayar University. Department of Gastroenterology. Manisa. TR
  • Akarca, U. S; Ege University. Department of Gastroenterology. Izmir. TR
  • Yuceyar, H; Celal Bayar University. Department of Gastroenterology. Manisa. TR
Braz. j. med. biol. res ; 36(6): 747-751, June 2003. tab
Article in English | LILACS | ID: lil-340662
ABSTRACT
The etiology of functional dyspepsia is not known. The objective of the present study was to determine the characteristics of functional dyspepsia in Western Turkey. We divided 900 patients with functional dyspepsia into three subgroups according to symptoms ulcer-like (UL), 321 (35.6 percent), motility disorder-like (ML), 281 (31.2 percent), and the combination (C) of these symptoms, 298 (33.1 percent). All patients were submitted to endoscopic evaluation, with two biopsies taken from the cardia and corpus, and four from the antrum of the stomach. All biopsy samples were studied for Helicobacter pylori (Hp) density, chronic inflammation, activity, intestinal metaplasia, atrophy, and the presence of lymphoid aggregates by histological examination. One antral biopsy was used for the rapid urease test. Tissue cagA status was determined by PCR from an antral biopsy specimen by a random sampling method. We also determined the serum levels of tumor necrosis factor-alpha (TNF-alpha) and gastrin by the same method. Data were analyzed statistically by the Kolmogorov-Smirnov test and by analysis of variance. Hp and cagA positivity was significantly higher in the UL subgroup than in the others. The patients in the ML subgroup had the lowest Hp and cagA positivity and Hp density. The ML subgroup also showed the lowest level of Hp-induced inflammation among all subgroups. The serum levels of TNF-alpha and gastrin did not reveal any difference between groups. Our findings show a poor association of Hp with the ML subgroup of functional dyspepsia, but a stronger association with the UL and C subgroups
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Full text: Available Index: LILACS (Americas) Main subject: Helicobacter pylori / Helicobacter Infections / Dyspepsia Limits: Adult / Female / Humans / Male Country/Region as subject: Asia Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2003 Type: Article / Congress and conference Affiliation country: Turkey / United States Institution/Affiliation country: Celal Bayar University/TR / Ege University/TR / University of Nebraska Medical Center/US

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Full text: Available Index: LILACS (Americas) Main subject: Helicobacter pylori / Helicobacter Infections / Dyspepsia Limits: Adult / Female / Humans / Male Country/Region as subject: Asia Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2003 Type: Article / Congress and conference Affiliation country: Turkey / United States Institution/Affiliation country: Celal Bayar University/TR / Ege University/TR / University of Nebraska Medical Center/US