Chemotherapeutic effects on larval stages of Schistosoma mansoni during infection and re-infection of mice
Rev. Soc. Bras. Med. Trop
;
36(3): 335-341, maio-jun. 2003. tab, graf
Article
in English
| LILACS
| ID: lil-341057
ABSTRACT
The sensitivity of the larval stages of Schistosoma mansoni to chemotherapy with praziquantel and oxamniquine was tested in mice during primary and secondary infections and after different intervals from cercarial exposure. Worm recovery by perfusion of the porto-mesenteric system, followed by counting and a morphometric study of the parasite, allowed the conclusion that the relative resistance of the larval stages of S. mansoni to schistosomicide drugs, demonstrated in primary infections, also persists when the host is already infected. This indicates that a therapeutic failure may result when an infected host is treated some time after being re-infected, because of the presence of migrating, drug-resistant, immature forms of the parasite
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Oxamniquine
/
Praziquantel
/
Schistosoma mansoni
/
Schistosomicides
/
Anthelmintics
Limits:
Animals
Language:
English
Journal:
Rev. Soc. Bras. Med. Trop
Journal subject:
Tropical Medicine
Year:
2003
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Fundação Oswaldo Cruz/BR
Similar
MEDLINE
...
LILACS
LIS