Field evaluation of the whole blood immunochromatographic test for rapid bancroftian filariasis diagnosis in the northeast of Brazil
Rev. Inst. Med. Trop. Säo Paulo
;
45(3): 125-129, May-Jun. 2003.
Article
in English
| LILACS
| ID: lil-342163
RESUMO
This study evaluated the whole blood immunochromatographic card test (ICT card test) in a survey performed in Northeastern Brazil. 625 people were examined by the thick blood film (TBF) and ICT card test. Residents of a non-endemic area were also tested by the whole blood card test and Og4C3. The sensitivity of the ICT card test was 94.7 percent overall, but lower in females than males, based on the reasonable assumption that TBF is 100 percent specific. However, since TBF and other methods have unknown sensitivity, the true specificity of the card test is unknown. Nevertheless, it is possible to estimate upper and lower limits for the specificity, and relate it to the prevalence of the disease. In the endemic area, the possible range of the specificity was from 72.4 percent to 100 percent. 29.6 percent of the card tests performed in the non-endemic area exhibited faint lines that were interpreted as positives. Characteristics of the method including high sensitivity, promptness and simplicity justify its use for screening of filariasis. However, detailed information about the correct interpretation in case of extremely faint lines is essential. Further studies designed to consider problems arising from imperfect standards are necessary, as is a sounder diagnostic definition for the card test
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Reagent Kits, Diagnostic
/
Wuchereria bancrofti
/
Filariasis
/
Antigens, Helminth
Type of study:
Diagnostic study
/
Practice guideline
/
Prevalence study
/
Prognostic study
/
Risk factors
Limits:
Animals
/
Female
/
Humans
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Rev. Inst. Med. Trop. Säo Paulo
Journal subject:
Tropical Medicine
Year:
2003
Type:
Article
/
Project document
Affiliation country:
Brazil
/
United kingdom
Institution/Affiliation country:
Fundação Oswaldo Cruz/BR
/
London University/GB
/
Universidade Federal da Bahia/BR
/
Universidade Federal de Pernambuco/BR
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