Anticuerpos anti-transglutaminasa tisular: ¿una mejor prueba para detectar transgresiones menores de la dieta en pacientes celíacos? / Tissue transglutaminase antibodies: a better test to detec minor dietary trasgressions in celiac patients?
Rev. méd. Chile
;
131(1): 25-29, 2003. tab
Article
in Spanish
| LILACS
| ID: lil-342219
RESUMO
Background:
Endomysium antibodies (EMA) do not detect minor dietary transgressions in patients with celiac disease.Aim:
To compare the sensitivity and specificity of tissue transglutaminase antibodies (tTGA) and endomysium antibodies (EMA) in biopsy proven celiac patients at the time of diagnosis and during gluten free diet (GFD). Patients andmethods:
One hundred fifty three subjects were studied a) 30 healthy controls; b) 9 cases with cow's milk allergy; c) 24 celiac patients at time of diagnosis; d) 25 celiac patients adhering to the GFD; e) 65 celiac patients with poor/no adhesion to GFD. EMA and tTGA IgA were measured by immunofluorescence and ELISA, respectively.Results:
Sensitivity and specificity were 100 percent and 97.4 percent for tTGA, respectively. All patients with cow's milk allergy were EMA (-) and 8 of 9 (88.9 percent) were tTGA (-). In celiac patients not adhering to the GFD, EMA and tTGA positivity were similar (80 percent and 81,5 percent, respectively); 95,4 percent of the subjects tested positive for at least one of them. All patients adhering to GFD were EMA (-) but tTGA were (+) in 28 percent of them.Conclusions:
EMA and tTGA have similar sensitivity and specificity at the time of diagnosis of celiac disease. Positive tTGA in 28 percent of patients that adhered strictly to the GFD and whose EMA were negative suggest that tTGA may be helpful in detecting minor dietary transgressions and should be further evaluated
Full text:
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Index:
LILACS (Americas)
Main subject:
Celiac Disease
/
Transglutaminases
/
Antibody Specificity
Type of study:
Observational study
Limits:
Female
/
Humans
/
Male
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2003
Type:
Article
/
Project document
Affiliation country:
Chile
Institution/Affiliation country:
Universidad de Chile/CL
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