The association of genetic markers and malaria infection in the Brazilian Western Amazonian region
Mem. Inst. Oswaldo Cruz
;
98(4): 455-460, June 2003. mapas, tab
Article
in English
| LILACS
| ID: lil-344234
RESUMO
Almost all individuals (182) belonging to an Amazonian riverine population (Portuchuelo, RO, Brazil) were investigated for ascertaining data on epidemiological aspects of malaria. Thirteen genetic blood polymorphisms were investigated (ABO, MNSs, Rh, Kell, and Duffy systems, haptoglobins, hemoglobins, and the enzymes glucose-6-phosphate dehydrogenase, glyoxalase, phosphoglucomutase, carbonic anhydrase, red cell acid phosphatase, and esterase D). The results indicated that the Duffy system is associated with susceptibility to malaria, as observed in other endemic areas. Moreover, suggestions also arose indicating that the EsD and Rh loci may be significantly associated with resistance to malaria. If statistical type II errors and sample stratification could be ruled out, hypotheses on the existence of a causal mechanism or an unknown closely linked locus involved in susceptibility to malaria infection may explain the present findings
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Phenotype
/
Plasmodium falciparum
/
Plasmodium vivax
/
Malaria, Vivax
/
Malaria, Falciparum
/
Erythrocytes
Type of study:
Risk factors
Limits:
Animals
/
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2003
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Centro de Pesquisas em Doenças Tropicais/BR
/
Universidade de São Paulo/BR
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