Sequence and phylogenetic analysis of human T cell lymphotropic virus type 1 from Tumaco, Colombia
Mem. Inst. Oswaldo Cruz
;
98(5): 641-648, July 2003. ilus, tab, graf
Article
in English
| LILACS
| ID: lil-344283
ABSTRACT
Human T cell lymphotropic virus type 1 (HTLV-1) is a retrovirus that causes leukemia and the neurological disorder HTLV-1 associated myelopathy or tropical spastic paraparesis (HAM/TSP). Infection with this virus - although it is distributed worldwide - is limited to certain endemic areas of the world. Despite its specific distribution and slow mutation rate, molecular epidemiology on this virus has been useful to follow the movements of human populations and routes of virus spread to different continents. In the present study, we analyzed the genetic variability of a region of the env gene of isolates obtained from individuals of African origin that live on the Pacific coast of Colombia. Sequencing and comparison of the fragment with the same fragment from different HTLV-1 isolates showed a variability ranging from 0.8 percent to 1.2 percent. Phylogenetic studies permit us to include these isolates in the transcontinental subgroup A in which samples isolated from Brazil and Chile are also found. Further analyses will be necessary to determine if these isolates were recently introduced into the American continent or if they rather correspond to isolates introduced during the Paleolithic period
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Phylogeny
/
DNA, Viral
/
Human T-lymphotropic virus 1
/
Genes, env
Limits:
Humans
Country/Region as subject:
South America
/
Colombia
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2003
Type:
Article
Affiliation country:
Colombia
Institution/Affiliation country:
Universidad de Antioquia/CO
/
Universidad del Valle/CO
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