Eleutherinone, a novel fungitoxic naphthoquinone from Eleutherine bulbosa (Iridaceae)
Mem. Inst. Oswaldo Cruz
;
98(5): 709-712, July 2003. ilus, tab
Article
in English
| LILACS
| ID: lil-344294
ABSTRACT
The dichloromethane extract prepared from the underground parts of Eleutherine bulbosa (Miller) Urban (Iridaceae) showed strong activity in the direct bioautography assay with the phytopathogenic fungus Cladosporium sphaerospermum. This assay was used to guide the fractionation of this extract and allowed the isolation of four compounds the new naphthoquinone eleutherinone[8-methoxy-1-methyl-1,3-dihydro-naphtho(2,3-c)furan-4,9 -dione] and the known compounds, previously isolated from this species, eleutherin [9-methoxy-1(R),3(S)-dimethyl-3,4-dihydro-1H-benzo(g)isochromene-5,10-dione], isoeleutherin [9-methoxy-1(R),3(R)-dimethyl-3,4-dihydro-1H-benzo(g)isochromene-5,10-dione], and eleutherol [4-hydroxy-5-methoxy-3(R)-methyl-3H-naphtho(2,3-c)furan-1 -one]. All quinonoid compounds showed strong antifungal activity in the bioautography assay at 100 æg/spot, while eleutherol was inactive
Full text:
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Index:
LILACS (Americas)
Main subject:
Plant Extracts
/
Naphthoquinones
/
Cladosporium
/
Antifungal Agents
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2003
Type:
Article
Affiliation country:
Brazil
/
United States
Institution/Affiliation country:
Fiocruz/BR
/
Fundação Oswaldo Cruz/BR
/
University of California/US
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