Selection of 5-fluorocytosine-resistant mutants from an Aspergillus niger citric acid-producing strain
Braz. j. microbiol
;
34(1): 1-4, Jan.-Apr. 2003. tab
Article
in English
| LILACS
| ID: lil-344555
ABSTRACT
Mutants of Aspergillus niger N402, induced by UV mutagenesis, were selected and tested for resistance or sensitivity to 5-fluorocytosine. Some mutants showed increased citric acid production, which did not correlate with the intracellular amount of protein or ammonium ion. The resistance to 5-fluorocytosine proved to be a rational approach for isolation of new mutants with improved production of citric acid. The best mutant (FR13) accumulated double the amount of citric acid produced by the parental strain.
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Index:
LILACS (Americas)
Main subject:
Aspergillus niger
/
In Vitro Techniques
/
Mutagenesis
/
Citric Acid
/
Flucytosine
Language:
English
Journal:
Braz. j. microbiol
Journal subject:
Microbiology
Year:
2003
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Faculdade de Ciências Farmacêuticas de Ribeirão Preto/BR
/
Universidade de São Paulo/BR
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