Efficacy of acamprosate in the treatment of alcohol-dependent outpatients
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
;
25(3): 156-159, set. 2003. graf
Article
in English
| LILACS
| ID: lil-346990
ABSTRACT
OBJECTIVE:
To evaluate the efficacy and security of acamprosate in the treatment of 75 men, aged 18 to 59 years, with diagnosis of alcohol dependence according to the ICD-10.METHODS:
Double-blind, placebo-controlled study, 24-week long. After a one-week detoxification period, patients were randomly divided in two groups the first group received acamprosate (six tablets of 333 mg/d for 12 weeks) and the second group received placebo (six tablets for 12 weeks). After the first 12 weeks, patients continued the follow-up for further 12 weeks without medication.RESULTS:
Patients who were receiving acamprosate showed significantly higher continuous abstinence time within the 24 weeks of treatment compared with patients who were assigned to placebo treatment (p=.017). Twenty-five percent of patients who were receiving acamprosate and 20 percent of the placebo-treated patients dropped out. Few side-effects were reported in both groups.CONCLUSION:
Acamprosate proved to be safe and effective in treating alcohol-dependent patients and to maintain the abstinence during 24 weeks
Full text:
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Index:
LILACS (Americas)
Main subject:
Taurine
/
Alcohol Deterrents
/
Alcoholism
Type of study:
Controlled clinical trial
/
Observational study
/
Prognostic study
Limits:
Adolescent
/
Adult
/
Humans
/
Male
Language:
English
Journal:
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
Journal subject:
Psychiatry
Year:
2003
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
University of São Paulo/BR
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