Diffusion MRI studies in vascular cognitive impairment and dementia
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
;
25(3): 188-191, set. 2003. ilus
Article
in English
| LILACS
| ID: lil-346999
ABSTRACT
Since its introduction more than two decades ago, Magnetic Resonance Imaging (MRI) has not only allowed for visualization of the macrostructure of the CNS, but also has been able to study dynamic processes which constitute the substrate of currently available MRI variants. While conventional Diffusion Weighted Imaging (DWI) permits a robust visualization of lesions just a few minutes after the onset of cerebral ischemia, Diffusion Tensor Imaging (DTI) measures the magnitude and direction of diffusion, leading to the characterization of cerebral white matter (WM) microstructural integrity. In this paper, the potential role of MRI techniques, particularly DTI, for the study of the relationship between changes in the microstructural integrity of WM and cognitive impairment in the context of cerebrovascular disease are discussed. Significant correlations between scores of behavioral measures of cognitive function and regional anisotropy values are an example of the potential efficacy of DTI for in vivo studies of brain connectivity in vascular neurodegenerative conditions
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Magnetic Resonance Imaging
/
Dementia, Vascular
/
Cognition Disorders
Type of study:
Etiology study
Limits:
Humans
Language:
English
Journal:
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
Journal subject:
Psychiatry
Year:
2003
Type:
Article
Affiliation country:
United States
Institution/Affiliation country:
Rush University/US
/
The Chicago Medical School/US
/
University of Illinois at Chicago/US
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