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Effect of antihypertensive agents on stellate cells during liver regeneration in rats
Ramalho, Leandra N. Z; Zucoloto, Sérgio; Ramalho, Fernando S; Castro-e-silva Júnior, Orlando de; Corrêa, Fernando M. A.
  • Ramalho, Leandra N. Z; University of São Paulo. Faculty of Medicine of Ribeirão Preto. Departments of Pathology. Ribeirão Preto. BR
  • Zucoloto, Sérgio; University of São Paulo. Faculty of Medicine of Ribeirão Preto. Departments of Pathology. Ribeirão Preto. BR
  • Ramalho, Fernando S; University of São Paulo. Faculty of Medicine of Ribeirão Preto. Surgery and Anatomy. Ribeirão Preto. BR
  • Castro-e-silva Júnior, Orlando de; University of São Paulo. Faculty of Medicine of Ribeirão Preto. Surgery and Anatomy. Ribeirão Preto. BR
  • Corrêa, Fernando M. A; University of São Paulo. Faculty of Medicine of Ribeirão Preto. Pharmacology. Ribeirão Preto. BR
Arq. gastroenterol ; 40(1): 40-44, Jan.-Mar. 2003. ilus, graf
Article in English | LILACS | ID: lil-347610
ABSTRACT

BACKGROUND:

Although most studies have focused on the hepatocytes, all the hepatic cells participate in the regenerative process, among them the stellate cells. The stellate cells are mesenchymal cells involved in local neurotransmission and paracrine regulation of several liver functions. Acute hepatic tissue loss promotes the proliferation and activation of stellate cells from a quiescent state to myofibroblast-like cells.

AIM:

Investigate the effects of antihypertensive agents on the stellate cell population during the liver regenerative phenomenon in rats.

METHODS:

Adult male Wistar rats received lisinopril, losartan, bradykinin, or saline solution in a proportional volume, intraperitoneally, before and after 70 percent partial hepatectomy. Animals from the experimental and saline groups were sacrificed at 36 hours after partial hepatectomy. The alpha-smooth muscle actin labelled stellate cells population was counted in the periportal and pericentral zones of the liver specimen.

RESULTS:

The labelled stellate cells were more numerous in the control group both in the periportal and pericentral zones at 36 hours after partial hepatectomy than at the other times. The population of stellate cells was significantly lower in the losartan group and higher in the bradykinin and lisinopril groups than in the control group.

CONCLUSIONS:

These results suggest that losartan can inhibit and bradykinin and lisinopril can stimulate the stellate cell population during liver regeneration in rats. These cells synthesize several substances to stimulate liver regeneration.
Subject(s)
Full text: Available Index: LILACS (Americas) Main subject: Liver / Liver Regeneration / Antihypertensive Agents Limits: Animals Language: English Journal: Arq. gastroenterol Journal subject: Gastroenterology Year: 2003 Type: Article Affiliation country: Brazil Institution/Affiliation country: University of São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Liver / Liver Regeneration / Antihypertensive Agents Limits: Animals Language: English Journal: Arq. gastroenterol Journal subject: Gastroenterology Year: 2003 Type: Article Affiliation country: Brazil Institution/Affiliation country: University of São Paulo/BR