In vitro susceptibility characteristics of Cryptococcus neoformans varieties from AIDS patients in Goi⮩a, Brazil
Mem. Inst. Oswaldo Cruz
;
98(6): 839-841, Sept. 2003.
Article
in English
| LILACS
| ID: lil-348356
RESUMO
Sixty clinical isolates of Cryptococcus neoformans from AIDS from Goi⮩a, state of Goiᳬ Brazil, were characterized according to varieties, serotypes and tested for antifungal susceptibility. To differentiate the two varieties was used L-canavanine-glycine-bromothymol blue medium and to separate the serotypes was used slide agglutination test with Crypto Check Iatron. The Minimal Inhibitory Concentration (MIC) of fluconazole, itraconazole, and amphotericin B were determined by the National Committee for Clinical Laboratory Standards macrodilution method. Our results identified 56 isolates as C. neoformans var. neoformans serotype A and 4 isolates as C. neoformans var. gattii serotype B. MIC values for C. neoformans var. gattii were higher than C. neoformans var. neoformans. We verified that none isolate was resistant to itraconazole and to amphotericin B, but one C. neoformans var. neoformans and three C. neoformans var. gattii isolates were resistant to fluconazole. The presence of C. neoformans var. gattii fluconazole resistant indicates the importance of determining not only the variety of C. neoformans infecting the patients but also measuring the MIC of the isolate in order to properly orient treatment
Full text:
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Index:
LILACS (Americas)
Main subject:
Fluconazole
/
Amphotericin B
/
Itraconazole
/
Cryptococcus neoformans
/
Antifungal Agents
Type of study:
Practice guideline
/
Prognostic study
Limits:
Adult
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2003
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal de Goiás/BR
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