Hoffman's syndrome: pseudohypertrophic myopathy as initial manifestation of hypothyroidism. Case report
Arq. neuropsiquiatr
;
61(3B): 851-854, Sept. 2003. ilus, tab
Article
in English
| LILACS
| ID: lil-348677
ABSTRACT
The frequency of myopathy in hypothyroidism ranges from 30 to 80 percent. The major symptoms related are weakness, muscular cramps and myalgia. The pseudohyperthrophic form is called Hoffman's syndrome. The electrophysiological study reveals myopathy, neuropathy or mixed pattern. Laboratorial investigation generally shows increased levels of muscle enzymes and low serum thyroid hormones, with thyrotrophic-stimulating hormone (TSH) elevated. The treatment consists in hormone replacement and the prognosis is good in most of the cases. We report an adult male who developed muscular cramps, myalgia, weakness, pseudohyperthrophy, associated with facial edema and alteration of his voice. The muscle enzymes were increased and T4 was undetectable with a raised level of TSH. The myopathy was the initial manifestation of hypothyroidism in this case
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Muscle, Skeletal
/
Hypothyroidism
/
Muscular Diseases
Type of study:
Prognostic study
Limits:
Adult
/
Humans
/
Male
Language:
English
Journal:
Arq. neuropsiquiatr
Journal subject:
Neurology
/
Psychiatry
Year:
2003
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Institute of Neurology Deolindo Couto/BR
/
University Hospital Clementino Fraga Filho/BR
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