Stereological tools in biomedical research
An. acad. bras. ciênc
;
75(4): 469-486, Dec. 2003. ilus, tab
Article
in English
| LILACS
| ID: lil-348798
RESUMO
Stereological studies are more and more frequent in literature, particularly in the development/evolution, pathology, and neurosciences areas. The stereology challenge is to understand the structural inner threedimensional arrangement based on the analysis of the structure slices only showing two-dimensional information. Cavalieri and Scherle's methods to estimate volume, and Buffon's needle problem, are commented in the stereological context. A group of actions is needed to appropriately quantify morphological structures (unbiased and reproducibly), e.g. sampling, isotropic and uniform randomly sections (Delesse's principle), and updated stereological tools (disector, fractionator, nucleator, etc). Through the correct stereology use, a quantitative study with little effort could be performed efficiency in stereology means a minimum slices sample counting (little work), low cost (slices preparation), but good accuracy. In the present text, a short review of the main stereological tools is done as a background basis to non-expert scientists
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Research
/
Stereotaxic Techniques
Limits:
Humans
Language:
English
Journal:
An. acad. bras. ciênc
Journal subject:
Science
Year:
2003
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade do Estado do Rio de Janeiro/BR
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