Duration-controlled swimming exercise training induces cardiac hypertrophy in mice
Braz. j. med. biol. res
;
36(12): 1751-1759, Dec. 2003. ilus, tab
Article
in English
| LILACS
| ID: lil-350460
RESUMO
Exercise training associated with robust conditioning can be useful for the study of molecular mechanisms underlying exercise-induced cardiac hypertrophy. A swimming apparatus is described to control training regimens in terms of duration, load, and frequency of exercise. Mice were submitted to 60- vs 90-min session/day, once vs twice a day, with 2 or 4 percent of the weight of the mouse or no workload attached to the tail, for 4 vs 6 weeks of exercise training. Blood pressure was unchanged in all groups while resting heart rate decreased in the trained groups (8-18 percent). Skeletal muscle citrate synthase activity, measured spectrophotometrically, increased (45-58 percent) only as a result of duration and frequency-controlled exercise training, indicating that endurance conditioning was obtained. In groups which received duration and endurance conditioning, cardiac weight (14-25 percent) and myocyte dimension (13-20 percent) increased. The best conditioning protocol to promote physiological hypertrophy, our primary goal in the present study, was 90 min, twice a day, 5 days a week for 4 weeks with no overload attached to the body. Thus, duration- and frequency-controlled exercise training in mice induces a significant conditioning response qualitatively similar to that observed in humans.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Physical Conditioning, Animal
/
Swimming
/
Cardiomegaly
Limits:
Animals
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
2003
Type:
Article
/
Project document
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade de São Paulo/BR
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