The secondary alcohol and aglycone metabolites of doxorubicin alter metabolism of human erythrocytes
Braz. j. med. biol. res
;
36(12): 1643-1651, Dec. 2003. ilus, tab
Article
in English
| LILACS
| ID: lil-350464
RESUMO
Anthracyclines, a class of antitumor drugs widely used for the treatment of solid and hematological malignancies, cause a cumulative dose-dependent cardiac toxicity whose biochemical basis is unclear. Recent studies of the role of the metabolites of anthracyclines, i.e., the alcohol metabolite doxorubicinol and aglycone metabolites, have suggested new hypotheses about the mechanisms of anthracycline cardiotoxicity. In the present study, human red blood cells were used as a cell model. Exposure (1 h at 37ºC) of intact human red blood cells to doxorubicinol (40 µM) and to aglycone derivatives of doxorubicin (40 µM) induced, compared with untreated red cells...
Full text:
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Index:
LILACS (Americas)
Main subject:
Pentose Phosphate Pathway
/
Doxorubicin
/
Erythrocytes
/
Antibiotics, Antineoplastic
Limits:
Humans
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
2003
Type:
Article
Affiliation country:
Italy
Institution/Affiliation country:
Istituto di Chimica del Riconoscimento Molecolare/IT
/
Università Cattolica del Sacro Cuore/IT
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