Intermittent diazepam and continuous phenobarbital to treat recurrence of febrile seizures: a systematic review with meta-analysis
Arq. neuropsiquiatr
;
61(4): 897-901, Dec. 2003. tab
Article
in English
| LILACS
| ID: lil-352421
ABSTRACT
Convulsions triggered by fever are the most common type of seizures in childhood, and 20 percent to 30 percent of them have recurrence. The prophylactic treatment is still controversial, so we performed a systematic review to find out the effectiveness of continuous phenobarbital and intermittent diazepam compared to placebo for febrile seizure recurrence. METHOD:
Only randomized, double-blind, placebo-controlled trials were analyzed. The recurrence of febrile seizure was assessed for each drug.RESULTS:
Ten eligible clinical trials were included. Febrile seizure recurrence was smaller in children treated with diazepam or phenobarbital than in placebo group. Prophylaxis with either phenobarbital or diazepam reduces recurrences of febrile seizures. The studies were clinical, methodological, and statistically heterogeneous.CONCLUSION:
The effectiveness of phenobarbital and diazepam could not be demonstrated because clinical trials were heterogeneous, and the recommendation for treatment recurrence should rely upon the experience of the assistant physician yet
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Phenobarbital
/
Seizures, Febrile
/
Diazepam
/
Anticonvulsants
Type of study:
Controlled clinical trial
/
Etiology study
/
Practice guideline
/
Observational study
/
Prognostic study
/
Risk factors
/
Systematic reviews
Limits:
Humans
Language:
English
Journal:
Arq. neuropsiquiatr
Journal subject:
Neurology
/
Psychiatry
Year:
2003
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Federal University of São Paulo/BR
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