Transtorno obsessivo-compulsivo resistente: conceito e estratégias de tratamento
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
;
23(supl.2): 52-57, out. 2001. ilus, tab
Article
in Portuguese
|
LILACS-Express
| LILACS
| ID: lil-352869
RESUMO
Despite the fact that majority of OCD patients responds to conventional treatments, about 40 percent remain symptomatic after appropriate trials with serotonin uptake inhibitors (SRIs) or behavioral therapy. A patient is considered treatment-resistant after failing to respond to three pharmacological trials with SRIs as well as to behavior therapy. When all somatic strategies have been tried, including augmentation with other medications, and the patient remains symptomatic, he or she is considered treatment refractory. The concepts of resistance and refractoriness are briefly revised, and the current augmentation strategies, as well as non-pharmacological approaches such as neurosurgery and transcranial magnetic stimulation, are addressed in this paper. Finally, issues of predictive response factors, pharmacogenetics, and the pathophysiology of resistant cases are suggested as targets for further researches
Full text:
Available
Index:
LILACS (Americas)
Type of study:
Prognostic study
Language:
Portuguese
Journal:
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
Journal subject:
Psychiatry
Year:
2001
Type:
Article
/
Project document
Affiliation country:
Brazil
Institution/Affiliation country:
Instituto de Psiquiatria e Saúde Mental do Rio Grande do Sul/BR
/
Universidade de Säo Paulo/BR
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