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Prevalence of antinuclear autoantibodies in the serum of normal blood dornors
Fernandez, Solange Assuncion Villagra; Lobo, Alice Zoghbi Coelho; Oliveira, Zilda Najjar Prado de; Fukumori, Ligia Maria Ichimura; Périgo, Alexandre Marques; Rivitti, Evandro A.
  • Fernandez, Solange Assuncion Villagra; University of Säo Paulo. Hospital das Clínicas. Immunopathology Laboratory. Department of Dermatology. Säo Paulo. BR
  • Lobo, Alice Zoghbi Coelho; University of Säo Paulo. Hospital das Clínicas. Immunopathology Laboratory. Department of Dermatology. Säo Paulo. BR
  • Oliveira, Zilda Najjar Prado de; University of Säo Paulo. Hospital das Clínicas. Immunopathology Laboratory. Department of Dermatology. Säo Paulo. BR
  • Fukumori, Ligia Maria Ichimura; University of Säo Paulo. Hospital das Clínicas. Immunopathology Laboratory. Department of Dermatology. Säo Paulo. BR
  • Périgo, Alexandre Marques; University of Säo Paulo. Hospital das Clínicas. Immunopathology Laboratory. Department of Dermatology. Säo Paulo. BR
  • Rivitti, Evandro A; University of Säo Paulo. Hospital das Clínicas. Immunopathology Laboratory. Department of Dermatology. Säo Paulo. BR
Rev. Hosp. Clin. Fac. Med. Univ. Säo Paulo ; 58(6): 315-319, 2003. tab, graf
Article in English | LILACS | ID: lil-354165
RESUMO

OBJECTIVE:

To examine the presence of serum antinuclear autoantibodies in a healthy population.

METHODS:

Serum of 500 normal blood donors between 18 and 60 years of age were tested for the presence of autoantibodies. Antinuclear antibodies were detected by indirect immunofluorescence technique using HEp-2 epithelial cells as the substrate. The presence of dnaN was detected by indirect immunofluorescence technique using Critidia lucillae as the substrate. Anti-SSA (RO), anti-SSB (LA), anti-Sm, and anti-RNP were determined by double radial immunodiffusion.

RESULTS:

In the evaluation of the presence of serum antibodies, antinuclear antibodies were detected in 22.6 percent of the sera. The presence of other antibodies was not significant. The majority of the titers were 140.

CONCLUSION:

The presence of autoantibodies is not necessarily pathologic and has to be related to the age group, gender, and clinical condition of the patient
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Full text: Available Index: LILACS (Americas) Main subject: Autoantibodies / Antibodies, Antinuclear Type of study: Prevalence study / Risk factors Limits: Humans Language: English Journal: Rev. Hosp. Clin. Fac. Med. Univ. Säo Paulo Journal subject: Medicine Year: 2003 Type: Article Affiliation country: Brazil Institution/Affiliation country: University of Säo Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Autoantibodies / Antibodies, Antinuclear Type of study: Prevalence study / Risk factors Limits: Humans Language: English Journal: Rev. Hosp. Clin. Fac. Med. Univ. Säo Paulo Journal subject: Medicine Year: 2003 Type: Article Affiliation country: Brazil Institution/Affiliation country: University of Säo Paulo/BR