Longitudinal comparison between plasma and seminal HIV-1 viral loads during antiretroviral treatment
Rev. Soc. Bras. Med. Trop
; 36(6): 689-694, nov.-dez. 2003. tab, graf
Article
in En
| LILACS
| ID: lil-355345
Responsible library:
BR1.1
ABSTRACT
This study was designed to investigate the impact of anti-retroviral therapy on both plasma and seminal HIV-1 viral loads and the correlation between viral loads in these compartments after treatment. Viral load, CD4+ and CD8+ T-cell counts were evaluated in paired plasma and semen samples from 36 antiretroviral therapy-naïve patients at baseline and on days 45, 90, and 180 of treatment. Slopes for blood and seminal viral loads in all treated patients were similar (p = 0.21). Median HIV-1 RNA titers in plasma and semen at baseline were 4.95 log10 and 4.48 log10 copies/ml, respectively. After 180 days of therapy, the median viral load declined to 3.15 log10 copies/ml (plasma) and 3.2 log10 copies/ml (semen). At this timepoint 22 patients presented HIV-1 viral load below 400 copies/ml in either plasma or semen, but only 9 had viral loads below 400 copies/ml in both compartments.
Full text:
1
Index:
LILACS
Main subject:
Semen
/
HIV Infections
/
HIV-1
/
CD4-CD8 Ratio
/
Anti-HIV Agents
/
Viral Load
Type of study:
Observational_studies
Limits:
Humans
/
Male
Language:
En
Journal:
Rev. Soc. Bras. Med. Trop
Journal subject:
MEDICINA TROPICAL
Year:
2003
Type:
Article