Down-modulation of lymphoproliferation and interferon-gamma production by beta-glucan derived from Saccharomyces cerevisiae
Mem. Inst. Oswaldo Cruz
; 98(8): 1083-1087, Dec. 2003. graf
Article
in En
| LILACS
| ID: lil-355752
Responsible library:
BR1.1
ABSTRACT
Beta-glucan, one of the major cell wall components of Saccharomyces cerevisiae, has been found to enhance immune functions. This study investigated in vivo and in vitro effects of beta-glucan on lymphoproliferation and interferon-gamma (IFN-gamma) production by splenic cells from C57BL/6 female mice. All experiments were performed with particulate beta-glucan derived from S. cerevisiae. Data demonstrated that both, i.p administration of particulate beta-glucan (20 or 100 µg/animal) and in vitro stimulation of splenic cells (20 or 100 µg/ml of culture) decreased lymphoproliferation and IFN-gamma production induced by concanavalin A. These results suggest that beta-glucan can trigger a down-modulatory effect regulating a deleterious immune system hyperactivity in the presence of a strong stimulus.
Full text:
1
Index:
LILACS
Main subject:
Saccharomyces cerevisiae
/
Spleen
/
Lymphocyte Activation
/
Adjuvants, Immunologic
/
Interferon-gamma
/
Glucans
Limits:
Animals
Language:
En
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
MEDICINA TROPICAL
/
PARASITOLOGIA
Year:
2003
Type:
Article