Trypanosoma cruzi: genetic structure of populations and relevance of genetic variability to the pathogenesis of chagas disease
Mem. Inst. Oswaldo Cruz
;
99(1): 1-12, Feb. 2004. ilus, tab
Article
in English
| LILACS
| ID: lil-356435
ABSTRACT
Chagas disease, caused by the protozoan Trypanosoma cruzi, has a variable clinical course, ranging from symptomless infection to severe chronic disease with cardiovascular or gastrointestinal involvement or, occasionally, overwhelming acute episodes. The factors influencing this clinical variability have not been elucidated, but it is likely that the genetic variability of both the host and the parasite are of importance. In this work we review the the genetic structure of T. cruzi populations and analyze the importance of genetic variation of the parasite in the pathogenesis of the disease under the light of the histotropic-clonal model.
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LILACS (Americas)
Main subject:
Trypanosoma cruzi
/
Chagas Disease
Type of study:
Etiology study
/
Prognostic study
Limits:
Animals
/
Humans
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2004
Type:
Article
Affiliation country:
Brazil
/
United States
Institution/Affiliation country:
Harvard Medical School/US
/
Universidade Federal de Minas Gerais/BR
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