Human herpesvirus-8 (HHV-8) antibodies in women from São Paulo, Brazil: association with behavioral factors and Kaposi's sarcoma
Braz. j. infect. dis
;
7(6): 395-401, dez. 2003. tab
Article
in English
| LILACS
| ID: lil-357651
RESUMO
BACKGROUND:
With the spread of AIDS, many HIV-infected women have been diagnosed with Kaposi's sarcoma (KS), especially in Africa. Since the discovery of a novel herpesvirus as the causative agent of KS (human herpesvirus 8 - HHV-8) several seroepidemiological studies have been conducted to identify groups at risk for KS. The risk for women in Brazil has not been studied. MATERIALS ANDMETHODS:
We searched for HHV-8 antibodies in sera obtained from a bank made up of samples from 3 groups of individuals Group I 163 HIV-1-infected women attended at an ambulatory clinic in 1994; Group II 108 children born to HIV-1-infected mothers from 1990 to 1992, their antibodies reflected maternal infection, and Group III 630 HIV-1-seronegative, healthy women. In-house immunofluorescence and Western-Blot assays based on the BCBL-1 cell line were used to detect anti-latent and anti-lytic HHV-8 antibodies.RESULTS:
Group I had an overall frequency of antibodies of 8.6 percent, with a 1.2 percent frequency of anti-latent antibodies and an 8.0 percent frequency of anti-lytic antibodies. Similar results were detected in Group II, i.e., no cases with anti-latent antibodies and a 7.4 percent frequency of anti-lytic antibodies. In contrast, prevalences of 1.1 percent anti-latent antibodies and 0.3 percent anti-lytic antibodies were observed in Group III.CONCLUSIONS:
The epidemiologic pattern of HHV-8 in women from São Paulo varies according to behavioral factors, with emphasis on the sexual and blood routes of virus transmission/acquisition. Although HHV-8 anti-lytic antibodies were found in HIV-1-infected women, no case of KS was detected. Protective factors against KS are probably related to gender and/or to antiretroviral therapies introduced in Brazil since 1994.
Full text:
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Index:
LILACS (Americas)
Main subject:
Sarcoma, Kaposi
/
Herpesvirus 8, Human
/
Antibodies, Viral
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
Limits:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
/
Infant, Newborn
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Braz. j. infect. dis
Journal subject:
Communicable Diseases
Year:
2003
Type:
Article
/
Congress and conference
/
Project document
Affiliation country:
Brazil
Institution/Affiliation country:
Secretary of Health of São Paulo/BR
/
University of São Paulo/BR
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