Predictive value of PSA velocity over early clinical and pathological parameters in patients with localized prostate cancer who undergo radical retropubic prostatectomy
Int. braz. j. urol
;
30(1): 12-17, Jan.-Feb. 2004. tab
Article
in English
| LILACS
| ID: lil-359778
RESUMO
OBJECTIVES:
To analyze the behavior of the prostate specific antigen velocity (PSAV) in localized prostate adenocarcinoma. MATERIALS ANDMETHODS:
We conducted a retrospective study of 500 men who had localized prostate adenocarcinoma, who underwent radical retropubic prostatectomy between January 1986 and December 1999. The PSAV was calculated for each patient and subsequently, the values were correlated with 5 groups age, initial PSA value, clinical stage, tumor volume and Gleason score.RESULTS:
The behavior of PSAV presented statistic significance with an increment between 1.3 ng/mL and 9.6 ng/mL, ranging from 38.6 percent and 59.8 percent when compared with the initial PSA value (p < 0.0001), clinical stage (p = 0.0002), tumor volume (p < 0.0001) and Gleason score (p = 0.0009).CONCLUSION:
PSAV up to 2.5 ng/mL/year is associated with factors of good prognosis, such as initial PSA below 10 mg/mL, clinical stage T1, tumor volume below 20 percent and Gleason score lower than 7.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Prostatectomy
/
Prostatic Neoplasms
/
Adenocarcinoma
/
Prostate-Specific Antigen
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adult
/
Aged
/
Humans
/
Male
Language:
English
Journal:
Int. braz. j. urol
Journal subject:
Urology
Year:
2004
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Federal University of São Paulo/BR
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