Mecanismo inhibidor COX-2 y COX-3 en el daño gastrointestinal inducido por AINE en ratas / Mechanism of inhibition OF COX-2 and COX-3 in gastrointestinal damage induced by NSAID in rats
Acta gastroenterol. latinoam
;
33(4): 183-185, 2003. tab
Article
in Spanish
| LILACS
| ID: lil-359981
ABSTRACT
In randomized groups of Wistar rats, the effect inhibitor of selective NASAID over the COX-1, COX-2 and COX-3 the synchronizes inhibition of COX-1 and COX-2, COX-1 and COX-3, COX-2 and COX-3, and COX-1, COX-2 and COX-3 were studied. The conclusions were that the selective inhibition of COX-1, COX-2 and COX-3 no given gastrointestinal damage; the synchronizes inhibition of COX-1 and COX-2 given preferential gastric damage; in contrast the inhibition of COX-2 and COX-3 given massive necrosis preferential in small intestine.
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Index:
LILACS (Americas)
Main subject:
Anti-Inflammatory Agents, Non-Steroidal
/
Cyclooxygenase Inhibitors
/
Gastrointestinal Tract
/
Isoenzymes
Limits:
Animals
Language:
Spanish
Journal:
Acta gastroenterol. latinoam
Journal subject:
Gastroenterology
Year:
2003
Type:
Article
Affiliation country:
Argentina
Institution/Affiliation country:
Universidad Nacional de Rosario/AR
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